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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

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[Methanol poisonings in 2007-08].

Lars Slørdal¹, Anita Skogholt, Kjell Aarstad

¹Institutt for laboratoriemedisin, barne- og kvinnesykdommer, Norges teknisk-naturvitenskapelige universitet og Avdeling for klinisk farmakologi, St. Olavs hospital, Olav Kyrres gate 17, 7006 Trondheim, Norway. lars.slordal@ntnu.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|February 4, 2010

Summary

Four men died from methanol poisoning after drinking contaminated ethanol. Prompt investigation of methanol in deceased individuals is crucial to prevent further toxic exposures and identify contamination sources.

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Area of Science:

Toxicology
Forensic Science
Public Health

Background:

A cluster of four fatalities occurred in Norway around the 2007/2008 new year.
These deaths were linked to the ingestion of commercially available, purportedly denatured ethanol.

Observation:

The deceased individuals presented with symptoms consistent with severe poisoning.
Toxicological analysis of blood and urine samples from all four victims revealed high methanol concentrations.

Findings:

The ingested substance was identified as a mixture containing 70% methanol and 30% ethanol.
The methanol concentrations detected were lethal and indicative of methanol poisoning.

Implications:

These cases highlight the critical need for thorough toxicological investigations in unexplained deaths.
Prompt identification of methanol sources is essential to prevent further poisonings and protect public health.
Regulatory oversight and quality control of denatured alcohol products are paramount.