Vitreopapillary adhesion in macular diseases.

Area of Science:

• Ophthalmology
• Retinal Imaging
• Vitreoretinal Interface

Background:

• Vitreopapillary adhesion (VPA) is a poorly understood phenomenon.
• Its role in macular diseases requires further investigation.
• Advanced imaging techniques like SD-OCT/SLO are crucial for diagnosis.

Purpose of the Study:

• To identify and assess the prevalence of VPA in various macular diseases.
• To investigate the association between VPA and intraretinal cystoid spaces.
• To explore the potential impact of VPA on the vitreoretinal interface.

Main Methods:

• 99 subjects underwent ultrasonography and SD-OCT/SLO.
• Included patients with macular holes, lamellar holes, macular pucker, and dry AMD, plus controls.
• Evaluated posterior vitreous detachment (PVD), VPA, and cystoid spaces.

Main Results:

• VPA was most prevalent in macular holes (88.2%).
• VPA was significantly more common in macular holes compared to controls and other macular diseases.
• All macular hole eyes with VPA exhibited cystoid spaces; VPA was associated with cystoid spaces in macular pucker.

Conclusions:

• VPA is significantly associated with macular holes and may play a role in their pathogenesis.
• The presence of VPA in macular pucker is frequently linked to intraretinal cystoid spaces.
• VPA may influence forces at the vitreoretinal interface, potentially inducing cystoid spaces and holes.