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Related Experiment Video

Updated: Jun 16, 2026

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
05:44

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo

Published on: April 25, 2016

Three-dimensional macronutrient-associated Fos expression patterns in the mouse brainstem.

Jessica Schwarz1, Jasmine Burguet, Olivier Rampin

  • 1AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France.

Plos One
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

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Researchers identified distinct neuronal populations in the nucleus tractus solitarii (NTS) activated by different nutrients. This finding advances our understanding of how the brain processes food signals for meal termination.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Neuroanatomy

Background:

  • The caudal brainstem, including the nucleus tractus solitarii (NTS), is crucial for regulating meal termination and satiation.
  • Gastrointestinal signals about meal content reach the brainstem via the bloodstream or vagus nerve.
  • Limited knowledge exists regarding how specific macronutrient signals are encoded within the caudal brainstem.

Purpose of the Study:

  • To investigate whether sucrose and casein peptone activate spatially distinct subpopulations of NTS neurons.
  • To characterize these neuronal subpopulations using statistical three-dimensional modeling.

Main Methods:

  • Utilized immunolabeling of the proto-oncogene Fos as a marker for neuronal activity.
  • Employed statistical three-dimensional modeling to analyze neuronal density maps.

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Fluorescence Activated Cell Sorting (FACS) and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue
08:37

Fluorescence Activated Cell Sorting (FACS) and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue

Published on: August 27, 2016

Related Experiment Videos

Last Updated: Jun 16, 2026

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
05:44

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo

Published on: April 25, 2016

Fluorescence Activated Cell Sorting (FACS) and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue
08:37

Fluorescence Activated Cell Sorting (FACS) and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue

Published on: August 27, 2016

  • Compared Fos-positive neuron distribution following sucrose versus peptone gavage in mice.

    • Main Results:

    • Sucrose and peptone gavage activated distinct, though partially overlapping, NTS neuronal populations.
    • Sucrose activated neurons located more laterally (rostral NTS) and dorsally (caudal NTS) compared to peptone.
    • Demonstrated spatial segregation in the functional response of NTS neurons to different macronutrients.

    Conclusions:

    • This study is the first to distinguish NTS neuron subpopulations based on spatial functional responses to nutrients.
    • Findings suggest specific neuronal activity patterns are relevant for central encoding of GI macronutrient signals.
    • Highlights the utility of statistical three-dimensional modeling in functional neuroanatomy research.