Related Experiment Video

Updated: Jun 16, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

[Serum testosterone and cardiovascular disease in men]

Emmanuela Quental Callou de Sá1, Francisco Carleial Feijó de Sá, Alexis Dourado Guedes

  • 1Escola Paulista de Medicina, Unifesp, São Paulo, SP, Brasil. eqcallou@gmail.com

Arquivos Brasileiros De Endocrinologia E Metabologia
|February 4, 2010
PubMed

Insights

Testosterone levels in men may influence cardiovascular disease risk. Low testosterone is linked to metabolic syndrome components, but more research is needed to clarify its role in male heart health.

Area of Science:

  • Endocrinology
  • Cardiology
  • Men's Health

Context:

  • Cardiovascular diseases (CVD) are the leading cause of death in Brazil.
  • Men exhibit higher mortality from coronary artery disease and typically have higher testosterone levels than women.
  • Emerging research suggests androgens may exert beneficial or neutral effects on the male cardiovascular system.

Purpose:

  • To investigate the complex relationship between testosterone levels and cardiovascular health in men.
  • To explore the association between low endogenous testosterone and metabolic syndrome components.
  • To highlight the need for further research on testosterone's role in male CVD.

Summary:

  • Low testosterone levels in men are associated with metabolic syndrome factors like dyslipidemia, visceral obesity, hypertension, and thrombosis.
  • Existing data on testosterone's impact on vascular reactivity, atherosclerosis, and cardiovascular mortality in men is inconsistent.
  • Further large-scale, randomized, and prospective trials are essential to elucidate androgen-specific functions in male CVD.

Impact:

  • Clarify the role of testosterone in male cardiovascular disease pathogenesis.
  • Inform potential therapeutic strategies targeting androgen levels for CVD prevention or treatment in men.
  • Guide future research directions for understanding male-specific cardiovascular risks.

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...