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Updated: Jun 16, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Prostate cancer and acromegaly
Lívia L Corrêa1, Giovanna A Balarini Lima, Helena B de Melo Paiva
1Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Acromegaly patients show higher rates of prostate disorders, including enlargement and structural changes. Chronic growth hormone (GH) and insulin-like growth factor-I (IGF-I) excess may cause prostate hyperplasia, warranting further study.
Area of Science:
- Endocrinology
- Urology
- Oncology
Background:
- Acromegaly is associated with a higher prevalence of prostate disorders than in age-matched controls.
- Reported prostatic changes include enlargement, nodules, cysts, and calcifications.
- Prostate enlargement in young acromegalic patients with hypogonadism suggests a role for GH and IGF-I excess.
Purpose of the Study:
- To review prostate diseases in patients with acromegaly.
- To explore the link between acromegaly and prostatic hyperplasia.
- To discuss the potential association between acromegaly and prostate cancer.
Main Methods:
- Literature review of studies on acromegaly and prostate diseases.
- Analysis of reported prostatic structural changes in acromegalic patients.
- Examination of the relationship between GH/IGF-I and prostate growth.
Main Results:
- Acromegalic patients exhibit increased prostate size and structural abnormalities.
- Evidence suggests chronic GH and IGF-I excess contributes to prostate hyperplasia.
- The link between acromegaly and prostate cancer requires further investigation.
Conclusions:
- Acromegaly significantly impacts prostate health, leading to hyperplasia and structural changes.
- Long-term monitoring of acromegalic patients is crucial due to potential prostate cancer risks.
- Further research is needed to clarify the mechanisms and implications of these associations.
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