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Relationship between insulin and hypogonadism in men with metabolic syndrome
Amanda D A Caldas1, Adriana Lofrano Porto, Lucilia Domingues Casulari da Motta
1Departamento de Endocrinologia, Hospital das Forças Armadas, Brasília, DF, Brasil.
Objective:
To evaluate the incidence of hypogonadism in men with metabolic syndrome and its correlation with serum insulin levels.
Methods:
Observational, transversal study with 80 men with metabolic syndrome. The individuals were divided into two groups: Group 1: 56 patients (70%) with total testosterone > 300 ng/dL (normal gonadal function); Group 2: 24 patients (30%) with total testosterone < 300 ng/dL (hypogonadic).
Results:
The subjects from Group 2 compared to Group 1 presented higher body mass index (BMI), waist and hip circumferences, insulin, homeostasis model assessment insulin resistance index (Homa-IR) and beta cell (Homa-beta), and triglycerides, but lower SHBG and free testosterone values. Inverse correlations between insulin levels and total testosterone and SHBG, as well as between Homa-IR and total testosterone were observed.
Conclusion:
In this series of men with metabolic syndrome, hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities.
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