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Updated: Jun 16, 2026
Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats
Amália Cínthia Meneses do Rêgo1, Irami Araújo-Filho, Italo Medeiros Azevedo
1Department of Surgery, School of Medicine, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.
Purpose:
The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na(99m)Tc(-)) in organs and tissues of rats.
Methods:
Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1 mL of Na(99m)Tc(-) via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant.
Results:
Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups.
Conclusion:
This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na(99m)Tc(-).
