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Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
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Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Chapter 6--paracoccidioidomycosis.

Bodo Wanke1, Miguel Abidon Aidê

  • 1Department of Mycology, Evandro Chagas Hospital Research Center, Fundação Oswaldo Cruz - Fiocruz, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Jornal Brasileiro De Pneumologia : Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Paracoccidioidomycosis, a fungal infection endemic to Latin America, primarily affects children but can manifest chronically in adults. Diagnosis involves identifying Paracoccidioides brasiliensis in clinical samples, with itraconazole being a preferred treatment.

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Last Updated: Jun 16, 2026

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis
06:39

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Area of Science:

  • Mycology
  • Infectious Diseases
  • Tropical Medicine

Background:

  • Paracoccidioidomycosis is a systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis.
  • This disease is geographically restricted to Latin America and is the principal systemic mycosis in Brazil.
  • Infection occurs via inhalation of fungal propagules, with primary infection typically in childhood.

Purpose of the Study:

  • To provide a comprehensive overview of paracoccidioidomycosis, including its epidemiology, clinical presentation, diagnosis, and treatment.
  • To highlight the challenges in diagnosis and management of this neglected tropical disease.

Main Methods:

  • Diagnosis relies on identifying Paracoccidioides brasiliensis in clinical specimens through direct microscopy, culture, and histopathology.
  • Imaging techniques like Chest X-rays can reveal characteristic infiltrates.
  • Serological tests such as double agar gel immunodiffusion aid in diagnosis when fungal detection is difficult.

Main Results:

  • The most common chronic form in adults is multifocal, involving dissemination to lungs, lymph nodes, skin, and mucosae.
  • Symptoms include cough, dyspnea, and weight loss, with delayed diagnosis being common.
  • Histopathology shows the fungus with multiple budding, and Chest X-rays often reveal upper lobe reticulonodular infiltrates.

Conclusions:

  • Early diagnosis and appropriate treatment are crucial for managing paracoccidioidomycosis.
  • Itraconazole is the preferred treatment, while sulfamethoxazole-trimethoprim is common, and amphotericin B is reserved for severe cases.