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[Age-related changes of auditory event-related potential (P300) in children]
Y Naganuma1, T Konishi, M Murakami
1Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Insights
Auditory event-related potentials (ERPs) in children show developmental changes. ERPs provide objective measures for cognitive function assessment in childhood.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Cognitive Neuroscience
Context:
- Auditory event-related potentials (ERPs) are crucial for understanding auditory processing and cognitive function.
- Developmental changes in ERPs during childhood are not fully characterized.
- Establishing normative ERP values in children is essential for clinical applications.
Purpose:
- To investigate developmental changes in auditory event-related potentials (ERPs) in neurologically normal children aged 5 to 15.
- To establish normative data for ERP components (N100, P200, N200, P300) in childhood.
- To explore the relationship between age and ERP latencies and amplitudes.
Summary:
- Auditory ERPs (N100, P200, N200, P300) were recorded from 53 children (5-15 years) and 8 adults using an auditory oddball paradigm.
- A significant negative correlation was found between P300 latency and age (latency (msec) = -9.81 X Age + 459, r = 0.75, p < 0.01), with mild negative correlations for N100, P200, and N200 latencies.
- P300 topography evolved from varied patterns in early childhood to a consistent Pz maximum in adolescence, indicating maturational changes.
Impact:
- Auditory ERPs are easily measurable in children, offering a valuable tool for objective cognitive function evaluation.
- These findings contribute to normative data for pediatric ERP research.
- Understanding developmental trajectories of ERPs aids in identifying potential neurological or cognitive impairments in children.
Abstract:
Auditory event-related potentials (ERPs) were recorded from 53 neurologically normal children of 5 to 15 years of age, and 8 healthy adults. To clarify the developmental changes and to obtain a normative value in childhood, the latency and amplitude of ERPs (N100, P200, N200, and P300) were examined. ERPs were elicited with the auditory oddball paradigm. P300 components were detected in all subjects. A strong positive correlation was demonstrated between latencies of two trials, and a small latency difference between trials was interpreted as being clinically unimportant. A significant negative correlation was observed between P300 latency and age during childhood (latency (msec) = -9.81 X (Age) + 459: r = 0.75, p less than 0.01). A mild negative correlation was also observed between N100, P200 and N200 latency and age. P300-topography of amplitude showed various patterns in young childhood, but in adolescence a maximum point was Pz in almost all subjects. These findings suggest that auditory ERPs can be easily measured in childhood and are useful for objective evaluation of the cognitive function.