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Updated: Jun 16, 2026
10:30
Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
Biology of interleukin-22
Kerstin Wolk1, Ellen Witte, Katrin Witte
1University Hospital Charité, Berlin, Germany. kerstin.wolk@charite.de
Seminars in Immunopathology
|February 4, 2010
Summary
Interleukin-22 (IL-22) is a cytokine that primarily acts on epithelial cells, enhancing antimicrobial defense and tissue repair. It plays a key role in inflammation, immunity, and disease pathogenesis.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Interleukin-22 (IL-22) is a cytokine belonging to the IL-10 family.
- It is produced by various immune cells, including T helper (Th)22, Th1, Th17 cells, and others.
- IL-22 signaling involves a receptor complex (IL-22R1/IL-10R2) and JAK-STAT pathways.
Purpose of the Study:
- To provide a comprehensive overview of IL-22.
- To detail its gene, protein structure, cellular sources, receptors, and target cells.
- To elucidate its biological effects and roles in disease.
Main Methods:
- Literature review and synthesis of existing research on IL-22.
- Analysis of IL-22's molecular mechanisms and cellular interactions.
- Examination of IL-22's involvement in various pathological conditions.
Main Results:
- IL-22 primarily targets epithelial cells and hepatocytes, not mediating immune cell communication.
- It promotes antimicrobial defense, tissue regeneration, and protection against damage.
- IL-22 induces acute phase reactants and certain chemokines.
Conclusions:
- IL-22 is a crucial cytokine for epithelial barrier integrity and host defense.
- Its dysregulation is implicated in chronic inflammatory diseases, tumor progression, and infections.
- Understanding IL-22's multifaceted roles is vital for therapeutic strategies.
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