Mathematical models of naturally "morphed" human erythrocytes: stomatocytes and echinocytes

We present two mathematical models that describe human red blood cells (RBCs) with morphologies that are attained naturally under certain patho-physiological conditions, namely stomatocytes and echinocytes. Muñoz San Martín et al. (Bioelectromagnetics 27:521-527, 2006) recently presented models of these shapes based on our previous set of parametric equations (Kuchel and Fackerell, Bull. Math. Biol. 61:209-220, 1999) that involve Jacobi elliptic functions and integrals. Thus, both discocytes and stomatocytes are described. Here, we derived the Cartesian forms of these new equations; and, in addition, present a realistic model of a Type III echinocyte, using prolate spheroids 'decorating' a central sphere at the vertices of an internal dodecahedron. The RBC models based on Cartesian equations have been used for representing the shape changes (morphological transformations or "morphing") that occur in RBCs under various experimental conditions; specifically, when the shape changes have been monitored by nuclear magnetic resonance (NMR) micro-imaging.