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The dog as an animal model for DISH?
H C Kranenburg1, L A Westerveld, J J Verlaan
1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, PO Box 80154, 3508 TD Utrecht, The Netherlands.
Summary
Diffuse idiopathic skeletal hyperostosis (DISH) affects dogs, with a 3.8% prevalence. The Boxer breed shows a high prevalence, suggesting it may be a valuable animal model for studying this skeletal disorder in humans.
Area of Science:
- Veterinary Medicine
- Orthopedics
- Comparative Pathology
Background:
- Diffuse idiopathic skeletal hyperostosis (DISH) is a skeletal disorder affecting humans.
- Canine cases of DISH have been incidentally reported.
- Understanding DISH in dogs may offer insights into human disease.
Purpose of the Study:
- To determine the prevalence of DISH in skeletally mature dogs.
- To investigate the potential of dogs as an animal model for human DISH.
- To explore breed-specific predispositions for canine DISH.
Main Methods:
- Retrospective radiographic cohort study.
- Analysis of outpatient canine population.
- Age and sex demographic analysis.
Main Results:
- Overall canine DISH prevalence was 3.8%.
- Prevalence increased with age and was higher in males.
- Boxer dogs exhibited a significantly higher prevalence (40.6%).
Conclusions:
- Canine DISH prevalence is significant, particularly in older male dogs.
- The high prevalence in Boxers suggests a potential genetic basis.
- Boxer dogs may serve as a relevant animal model for human DISH research.
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