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Updated: Jun 16, 2026
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Recurrent choroidal melanoma after transscleral local resection with diffuse vitreous seeding
Pedro Gonzalez1, Ewan G Kemp, Fiona Roberts
1Tennent Institute of Ophthalmology, Western Infirmary, Glasgow G11 6NT, UK.
Summary
Recurrent choroidal melanoma after transscleral resection can spread within the eye through vitreous seeding. This uncommon intraocular spread may occur due to a compromised retinal barrier.
Area of Science:
- Ophthalmology
- Oncology
- Surgical Pathology
Background:
- Choroidal melanoma typically metastasizes via vascular or extraocular routes.
- Intraocular spread, particularly through vitreous seeding, is an infrequent occurrence in choroidal melanoma.
Observation:
- Two cases of recurrent choroidal melanoma post-transscleral local resection are presented.
- Gross examination revealed widespread fine patchy retinal pigmentation in both cases.
Findings:
- One patient exhibited recurrent melanoma with diffuse vitreous seeding and tumor cells in the anterior chamber.
- The second patient had satellite choroidal nodules with tumor cells in the vitreous and on the retinal surface.
Implications:
- Vitreous seeding following local resection of choroidal melanoma is uncommon.
- Loss of the retinal barrier is a likely factor facilitating intraocular spread in these cases.
