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Updated: Jun 16, 2026
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Quantification of the spatiotemporal microstructural organization of the human brain association, projection and
Khader M Hasan1, Arash Kamali, Humaira Abid
1Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston-Medical School, Houston, TX 77030, USA. Khader.M.Hasan@uth.tmc.edu
Abstract:
Using diffusion tensor tractography, we quantified the microstructural changes in the association, projection, and commissural compact white matter pathways of the human brain over the lifespan in a cohort of healthy right-handed children and adults aged 6-68 years. In both males and females, the diffusion tensor radial diffusivity of the bilateral arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, corticospinal, somatosensory tracts, and the corpus callosum followed a U-curve with advancing age; fractional anisotropy in the same pathways followed an inverted U-curve. Our study provides useful baseline data for the interpretation of data collected from patients.
