Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma.

Haematologica·2024
Same author

Osteocytes and Paget's Disease of Bone.

Current osteoporosis reports·2024
Same author

Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma.

Haematologica·2023
Same author

The acid-sensing nociceptor TRPV1 controls breast cancer progression in bone via regulating HGF secretion from sensory neurons.

Research square·2023
Same author

Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation.

JCI insight·2023
Same author

Doubling Down on Wnt Signaling to Overcome Myeloma Bone Disease.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2023
Same journal

Response to "Revisiting Inflammaging: A Critical Appraisal of Its Role in Alveolar Bone Loss".

Journal of bone and mineral metabolism·2026
Same journal

24-month real-world persistence and compliance of denosumab versus alendronate among postmenopausal women with osteoporosis in Australia, Taiwan, South Korea, Hong Kong, and Singapore.

Journal of bone and mineral metabolism·2026
Same journal

Eldecalcitol and calcium supplementation in Chinese women with postmenopausal osteoporosis: a prospective observational cohort study.

Journal of bone and mineral metabolism·2026
Same journal

Marrow fatty acids in osteoporosis: metabolic insights, emerging therapeutic targets.

Journal of bone and mineral metabolism·2026
Same journal

Revisiting inflammaging: a critical appraisal of its role in alveolar bone loss.

Journal of bone and mineral metabolism·2026
Same journal

Commentary on "Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study".

Journal of bone and mineral metabolism·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Targeting the bone microenvironment in multiple myeloma.

G David Roodman1

  • 1Department of Medicine/Hematology-Oncology, Veterans Affairs Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA. Roodmangd@upmc.edu

Journal of Bone and Mineral Metabolism
|February 4, 2010
PubMed
Summary
This summary is machine-generated.

Multiple myeloma bone disease involves osteolytic lesions and pain. New research identifies novel therapeutic targets beyond bisphosphonates for treating these bone complications.

More Related Videos

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
06:33

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

Related Experiment Videos

Last Updated: Jun 16, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
06:33

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

Area of Science:

  • Oncology
  • Bone Biology
  • Pharmacology

Background:

  • Multiple myeloma (MM) frequently causes debilitating bone disease, including osteolytic lesions and pain.
  • The bone marrow microenvironment significantly contributes to MM bone pathology.
  • Understanding osteoblast and osteoclast regulation is key to addressing MM bone disease.

Purpose of the Study:

  • To review potential novel therapeutic targets for MM bone disease.
  • To discuss emerging therapies currently in clinical trials for MM bone complications.

Main Methods:

  • Literature review of recent studies on MM bone disease.
  • Analysis of signaling pathways regulating bone metabolism in MM.
  • Examination of ongoing clinical trials for novel MM bone therapies.

Main Results:

  • Several novel targets for MM bone disease have been identified.
  • Emerging therapies show promise in clinical trials.
  • Enhanced understanding of the marrow microenvironment's role in MM bone disease.

Conclusions:

  • Novel therapeutic strategies targeting specific pathways offer new hope for MM patients with bone disease.
  • Further research and clinical trials are crucial for developing effective treatments for MM bone complications.