Screening of N-nitrosamines in tap and swimming pool waters using fast gas chromatography

N-Nitrosamines (NAms) are suspected human carcinogens that have been identified as drinking water and wastewater pollutants. In this work, a sensitive screening/confirmation method was proposed for the determination of the most toxic NAms that can be found in water samples (N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodibutylamine, N-nitrosomorpholine, N-nitrosopiperidine, and N-nitrosopyrrolidine). A sample volume of 250 mL was first preconcentrated in an automatic SPE unit and then the extract was concentrated to a final volume of 10 microL (providing a preconcentration factor of 25,000). Aliquots of the extract were subjected to a rapid screening process (1.6 min) by using a short capillary polar column (1.5 m length) and GC with nitrogen-phosphorous detection. In this way, the high number of samples to be tested routinely in a water laboratory is simplified due to a reduction in the analysis time. Thus, the screening method acts as a filter that indicates whether target analytes are present, above or below the cut-off level (3.8 or 10.4 ng/L), giving no false negatives at concentrations below the guide values for NAms in drinking water established by different countries. Positive samples (tap and swimming pool waters) were then confirmed by GC-MS detection.