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Updated: Jun 16, 2026

A Model of Chronic Nutrient Infusion in the Rat

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

The refeeding syndrome and glucose load.

Graeme O'Connor¹, Jonathon Goldin

¹Division of Nutrition and Dietetics, Great Ormond Street Children's Hospital, London, United Kingdom. graeme.oconnor@nhs.net

The International Journal of Eating Disorders

|February 4, 2010

Summary

Refeeding syndrome can occur even with cautious nutritional reintroduction in anorexia nervosa patients. This case highlights risks of hypophosphatemia, hypotension, and cardiac issues, even in young patients.

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Last Updated: Jun 16, 2026

A Model of Chronic Nutrient Infusion in the Rat

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Published on: August 14, 2013

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

Area of Science:

Pediatric Endocrinology
Nutritional Psychiatry
Clinical Case Study

Background:

Anorexia nervosa (AN) is a serious eating disorder with significant physical complications.
Refeeding syndrome (RS) is a potentially fatal complication of nutritional rehabilitation in malnourished individuals.
Early identification and management of RS are critical for patient outcomes.

Observation:

A 10-year-old female with anorexia nervosa developed refeeding syndrome despite a conservative refeeding protocol.
The patient experienced hypophosphatemia, hypotension, and cardiac abnormalities during nutritional reintroduction.
This case represents the youngest reported instance of refeeding syndrome in a patient with anorexia nervosa.

Findings:

Cautious refeeding, even at 25 kcal/kg, can precipitate refeeding syndrome.
Fluid shifts, glucose dysregulation, and electrolyte imbalances are key features of RS.
Carbohydrate intake may exacerbate the metabolic disturbances seen in refeeding syndrome.

Implications:

Clinicians must remain vigilant for refeeding syndrome in all anorexia nervosa patients, regardless of age or refeeding pace.
This case underscores the need for meticulous biochemical and physiological monitoring during nutritional rehabilitation.
Further research into the role of specific macronutrients, particularly carbohydrates, in precipitating refeeding syndrome is warranted.