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Updated: Jun 16, 2026

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane

Published on: November 28, 2019

Further observations on the empty "amnion sign".

N Tugce Yegul¹, Roy A Filly

¹Department of Radiology, University of California, San Francisco, L374, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA.

Journal of Clinical Ultrasound : JCU

|February 4, 2010

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The empty amnion sign, visualizing an amnion without an embryo, reliably diagnoses early pregnancy failure. This sign has a 100% positive predictive value, confirming non-viable pregnancies.

Area of Science:

Reproductive Medicine
Diagnostic Ultrasound
Embryology

Background:

Early pregnancy failure is a common complication.
Accurate diagnosis is crucial for patient management.
The "empty amnion sign" is a potential sonographic marker.

Purpose of the Study:

To evaluate the positive predictive value of the empty amnion sign.
To determine its diagnostic accuracy for early pregnancy failure.

Main Methods:

Retrospective analysis of 806 first-trimester sonographic examinations.
Inclusion criteria: abnormal findings in women with threatened abortion.
Assessment of "empty amnion sign" presence and pregnancy outcomes.

Main Results:

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Last Updated: Jun 16, 2026

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane

Published on: November 28, 2019

Dissection and Explant Culture of Murine Allantois for the In Vitro Analysis of Allantoic Attachment

Dissection and Explant Culture of Murine Allantois for the In Vitro Analysis of Allantoic Attachment

Published on: January 13, 2018

The empty amnion sign was observed in 71 of 286 cases (24.8%) without a visible embryo.
Mean sac diameters varied across the cohort.
All 68 cases with adequate follow-up confirmed pregnancy failure (100% positive predictive value).

Conclusions:

The empty amnion sign is a definitive sonographic marker for early pregnancy failure.
Diagnosis is reliable irrespective of mean sac diameter.
The sign demonstrates a high positive predictive value for confirming non-viable pregnancies.