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Anti-inflammatory function of Nodosin via inhibition of IL-2

Jiyu Li1, Junming Du, Lijuan Sun

  • 1Institute of Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, China. leejiyu@sina.com

The American Journal of Chinese Medicine
|February 4, 2010
PubMed

In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.

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