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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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[Reduced left ventricular systolic atrioventricular plane displacement in heart failure patients with preserved

Yong-Qiang Ren1, Wei Feng, Li Liu

  • 1Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|February 5, 2010
PubMed

Insights

Patients with preserved ejection fraction heart failure show impaired long-axis systolic function, indicated by reduced atrioventricular plane displacement (AVPD). This suggests systolic dysfunction alongside diastolic dysfunction in these patients.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized.
  • The underlying mechanisms of HFpEF, particularly systolic function, require further elucidation.
  • Traditional assessment focuses on ejection fraction, potentially overlooking other systolic impairments.

Purpose of the Study:

  • To investigate long-axis systolic function in patients with suspected heart failure and preserved left ventricular ejection fraction (LVEF).
  • To determine if left ventricular systolic atrioventricular plane displacement (AVPD) is impaired in HFpEF.
  • To compare AVPD between patients with preserved LVEF, reduced LVEF, and healthy controls.

Main Methods:

  • Retrospective analysis of 96 heart failure patients (48 HFpEF, 48 HFrEF) and 50 healthy controls.
  • Assessment of New York Heart Association (NYHA) classification, heart failure etiology, AVPD, and plasma NT-proBNP.
  • Statistical comparison of these parameters across the three groups.

Main Results:

  • No significant difference in NYHA class between HFpEF and HFrEF groups.
  • Hypertension and coronary heart disease were common etiologies in HFpEF.
  • AVPD was significantly reduced in HFrEF compared to HFpEF, and negatively correlated with NT-proBNP levels.

Conclusions:

  • Left ventricular systolic atrioventricular plane displacement (AVPD) is decreased in heart failure patients with preserved LVEF.
  • These findings indicate systolic dysfunction in the long axis of the left ventricle in HFpEF.
  • This suggests that HFpEF involves both diastolic and systolic impairments.
Abstract

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