Related Experiment Video
Updated: Jun 16, 2026

Immunofluorescent Detection of Two Thymidine Analogues (CldU and IdU) in Primary Tissue
Published on: December 7, 2010
Thymidine kinase and deoxycytidine kinase in HIV-infected children
Francesca Falasca1, Paola Maida, Arianna Boni
1Department of Experimental Medicine, Virology Section, "Sapienza" University of Rome, Italy.
Abstract:
It has been demonstrated that HIV infection may affect the levels of thymidine kinase (TK) and deoxycytidine kinase (dCK) in peripheral blood mononuclear cells from HIV infected adults. The aim of this study was to examine the effect of HIV infection and/or antiretroviral therapy on the activity of the above enzymes in HIV-infected children. The results showed that an inter-individual variability in TK and dCK activities does exist in both HIV infected and uninfected children. TK and dCK levels in PBMC from HIV infected and non infected children did not significantly differ. Furthermore, the therapeutic regimen, including zidovudine, does not seem to affect TK activity.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Antiviral Nucleoside Inhibitors
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Inhibition of Cdk Activity
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Cytomegalovirus Disease

