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Related Concept Videos

Endotracheal Intubation I: Procedure01:15

Endotracheal Intubation I: Procedure

Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...

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Related Experiment Video

Updated: Jun 16, 2026

A Simple Method of Mouse Lung Intubation
07:06

A Simple Method of Mouse Lung Intubation

Published on: March 21, 2013

Left-sided mouse intubation: description and evaluation.

Thomas Singer1, Vanessa Brand, Ueli Moehrlen

  • 1Internal Medicine V/Pulmonary Division, and Clinical and Experimental Surgery, University Hospital Homburg/Saar, University of Saarland, Germany.

Experimental Lung Research
|February 5, 2010
PubMed
Summary
This summary is machine-generated.

A novel technique enables precise left main bronchus intubation in mice using a modified catheter and wire guide. This method achieves over 80% success for targeted unilateral lung interventions.

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Area of Science:

  • Medical Devices
  • Animal Models
  • Respiratory Physiology

Background:

  • Accurate intubation is crucial for targeted lung interventions.
  • Existing methods for mouse intubation may lack precision for unilateral procedures.

Purpose of the Study:

  • To develop and validate a new technique for left main bronchus intubation in mice.
  • To facilitate precise delivery of substances to the left lung in preclinical research.

Main Methods:

  • A modified catheter and wire guide system was employed for transoral intubation.
  • Mice were anesthetized and positioned to straighten the airway for left main bronchus access.
  • Intubation was performed under direct vision using microscopic guidance.

Main Results:

  • The technique demonstrated a success rate exceeding 80% in 81 mice.
  • The method allows for wedge positioning of the catheter in the left main bronchus.
  • Successful intubation was achieved in mice weighing 23-48g.

Conclusions:

  • This wire guide-based method provides a reliable approach for left main bronchus intubation in mice.
  • The technique is suitable for unilateral lung interventions, including drug or substance delivery.
  • This advancement supports preclinical research requiring targeted lung administration in rodent models.