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Protein Glycosylation

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

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Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

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Glycome profiling using modern glycomics technology: technical aspects and applications.

Dieter Vanderschaeghe¹, Nele Festjens¹, Joris Delanghe²

¹Unit for Molecular Glycobiology, Department for Molecular Biomedical Research, VIB, Technologiepark 927, B-9052 Ghent, Belgium.

Biological Chemistry

|February 5, 2010

Summary

Glycomics analysis is crucial for understanding biological processes and diseases like cancer. This review details advancements in glycan profiling technologies, including electrophoresis, chromatography, and mass spectrometry, over the last five years.

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Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography

Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography

Published on: January 18, 2020

Area of Science:

Glycomics and glycobiology
Biochemistry and molecular biology
Disease biomarker research

Background:

Glycomics research is vital across diverse fields like immunity, signal transduction, and development.
Altered protein and lipid glycosylation is linked to various diseases, notably cancer.
Effective glycan analysis relies on advanced analytical technologies.

Purpose of the Study:

To review the evolution of glycan profiling tools over the past five years.
To highlight key analytical technologies for glycomics research.
To guide technology selection based on research needs (sensitivity, resolution, throughput).

Main Methods:

Capillary electrophoresis (CE)
Liquid chromatography (LC)
Mass spectrometry (MS)
Lectin microarrays

Main Results:

Significant advancements in glycan profiling technologies have been observed.
CE, LC, MS, and lectin microarrays represent key tools in modern glycomics.
These technologies offer varying capabilities to meet diverse research demands.

Conclusions:

The development of analytical technologies is essential for advancing glycomics.
Choosing the right technology is critical for successful glycan analysis.
Continued innovation in glycan profiling tools will further impact biological and medical research.