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Albumin production activity of primary rat hepatocytes is improved on type V collagen

Hiroyuki Ijima1, Ryohei Ogata, Yusuke Murasawa

  • 1Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, Japan. ijima@chem-eng.kyushu-u.ac.jp

Journal of Bioscience and Bioengineering
|February 5, 2010
PubMed

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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...