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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
HELP for AML: methylation profiling opens new avenues
Lars Bullinger1, Scott A Armstrong
1Department of Internal Medicine III, University of Ulm, 89081 Ulm, Germany.
Cancer Cell
|February 5, 2010
Abstract:
There is growing evidence that aberrant gene expression in cancer is linked to epigenetic deregulation like promoter cytosine methylation in CpG-islands. In this issue of Cancer Cell, Figueroa et al. show that genome-wide promoter DNA methylation profiling reveals unique AML subgroups and methylation patterns that are associated with clinical outcome.
