Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
13:21

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

HELP for AML: methylation profiling opens new avenues.

Lars Bullinger1, Scott A Armstrong

  • 1Department of Internal Medicine III, University of Ulm, 89081 Ulm, Germany.

Cancer Cell
|February 5, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid and Reproducible Karyotyping with Long Read Sequencing in AML Patients.

Blood advances·2026
Same author

Publisher Correction: Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia.

Genome biology·2026
Same author

Kidney Transplantation after Clearing Anti-HLA Antibodies with CD19 CAR T Cells.

The New England journal of medicine·2026
Same author

Clonal Hematopoiesis does not influence manufacturing of Chimeric Antigen Receptor (CAR) T-Cells.

Bone marrow transplantation·2026
Same author

A proposed refined definition of acute myeloid leukaemia patients ineligible for intensive therapy: The Integrated Comorbidity-ECOG-Age criteria.

British journal of haematology·2026
Same author

Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs.

Blood·2026
Same journal

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Cancer cell·2026
Same journal

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.

Cancer cell·2026
Same journal

Intratumoral B cells under stress.

Cancer cell·2026
Same journal

Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth.

Cancer cell·2026
Same journal

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.

Cancer cell·2026
Same journal

OpenIO: An open framework for AI-native immunotherapy.

Cancer cell·2026
See all related articles

Aberrant gene expression in cancer is linked to epigenetic changes. Genome-wide DNA methylation profiling identifies unique acute myeloid leukemia (AML) subgroups and methylation patterns linked to clinical outcomes.

Area of Science:

  • Oncology
  • Epigenetics
  • Genomics

Background:

  • Aberrant gene expression in cancer is increasingly linked to epigenetic deregulation.
  • Promoter cytosine methylation within CpG islands is a key epigenetic mechanism.
  • Understanding these patterns is crucial for cancer research and treatment.

Discussion:

  • Figueroa et al. demonstrate that genome-wide promoter DNA methylation profiling can identify distinct subgroups within acute myeloid leukemia (AML).
  • These methylation patterns correlate significantly with patient clinical outcomes.
  • This highlights the potential of epigenetic profiling in AML subtyping and prognosis.

Key Insights:

  • Genome-wide DNA methylation profiling is a powerful tool for classifying AML.
  • Specific DNA methylation patterns serve as biomarkers for clinical outcome in AML.

More Related Videos

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

Related Experiment Videos

Last Updated: Jun 16, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
13:21

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

  • Epigenetic deregulation plays a critical role in AML pathogenesis.

    • Outlook:

    • Further research can refine AML classification based on epigenetic signatures.
    • This approach may lead to more personalized treatment strategies for AML patients.
    • Epigenetic profiling could be extended to other cancer types for improved diagnostics.