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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Current strategies and recent advances in the therapy of hypercholesterolemia

E Windler1, B-Chr Zyriax, Chr Bamberger

  • 1Endokrinologie und Stoffwechsel des Alterns, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. windler@uke.uni-hamburg.de

Atherosclerosis. Supplements
|February 5, 2010
PubMed

Insights

Lipid therapy effectively prevents atherosclerotic vascular disease. New drugs like colesevelam, niacin/laropiprant, and mipomersen offer improved efficacy and tolerability for lowering LDL-cholesterol and raising HDL-cholesterol.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Atherosclerotic vascular disease prevention relies on lipid therapy.
  • Optimal LDL-cholesterol levels are below 100 mg/dl, necessitating potent lipid-lowering drugs.
  • Current strategies focus on inhibiting cholesterol synthesis and absorption.

Purpose of the Study:

  • To review advancements in lipid therapy for atherosclerotic vascular disease.
  • To highlight novel therapeutics enhancing efficacy and tolerability.
  • To discuss new agents for lowering LDL-cholesterol and raising HDL-cholesterol.

Main Methods:

  • Review of current and emerging lipid-lowering and HDL-raising therapeutics.
  • Discussion of drug mechanisms, efficacy, and tolerability profiles.
  • Comparison of novel agents with existing therapies and apheresis.

Main Results:

  • Colesevelam, a bile-acid sequestrant, offers improved tolerability.
  • Niacin combined with laropiprant significantly raises HDL-cholesterol with reduced flushing.
  • Mipomersen demonstrates substantial reduction in apolipoprotein B-100, challenging apheresis.

Conclusions:

  • New pharmacological developments promise enhanced lipid management for cardiovascular disease.
  • Combination therapies and novel agents like mipomersen represent significant progress.
  • These advancements aim to achieve lower LDL-cholesterol and improved HDL-cholesterol levels more effectively and safely.

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