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Updated: Jun 16, 2026
07:13
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
[Weaning from corticosteroid therapy after kidney transplantation]
M Hazzan1, F Glowacki, A Lionet
1Pôle de Néphrologie, CHRU de Lille, Hôpital Albert Calmette, Boulevard du Professeur Jules Leclercq, Lille Cedex, France. mhazzan@gmail.com
Nephrologie & Therapeutique
|February 5, 2010
Summary
Steroid withdrawal in renal transplantation is now safe with new immunosuppressants, reducing side effects like cardiovascular issues and infections. Long-term patient survival benefits require further study.
Area of Science:
- Nephrology
- Immunosuppression
- Transplantation immunology
Context:
- Long-term steroid use in renal transplantation presents numerous side effects.
- Historically, steroid withdrawal increased acute rejection and graft loss risks.
- Advancements in immunosuppressive therapies necessitate re-evaluation of steroid discontinuation.
Purpose:
- To assess the safety and efficacy of late steroid withdrawal in renal transplant recipients.
- To determine if modern immunosuppression mitigates risks associated with steroid discontinuation.
Summary:
- Recent trials indicate that late steroid withdrawal (3 months post-transplant) is not associated with increased acute rejection or graft loss when using newer immunosuppressants like tacrolimus, mycophenolate, and mTOR inhibitors.
- Studies show improvements in cardiovascular risk factors, reduced infections, and decreased osteoporosis incidence following steroid withdrawal.
- The long-term impact on patient survival post-renal transplant requires further investigation.
Impact:
- Facilitates steroid-free immunosuppression protocols in renal transplantation.
- Potentially improves patient quality of life by reducing steroid-related adverse events.
- Contributes to optimizing long-term outcomes in kidney transplant recipients.
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