Related Experiment Video
Updated: Jun 16, 2026

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
Published on: August 29, 2017
A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck
Kyoko Shinya1, Akiko Makino, Masato Hatta
1Division of Zoonosis, Department of Microbiology and Infectious Diseases, Graduate School of Medicine, Kobe University 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan. kyoko.tanaka@aioros.ocn.ne.jp
Abstract:
A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage.
More Related Videos
07:15Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity
Published on: November 22, 2021
09:02Monitoring Influenza Virus Survival Outside the Host Using Real-Time Cell Analysis
Published on: February 20, 2021
Related Concept Videos
Viral Mutations
Viral Recombination
Leaky Scanning
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Influenza