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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

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Related Experiment Video

Updated: Jun 16, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Arsenical peripheral neuropathy.

Liberty Mathew1, Allister Vale, Jane E Adcock

  • 1Department of Neurology, West Wing, John Radcliffe Hospital, Oxford, UK.

Practical Neurology
|February 5, 2010
PubMed
Summary
This summary is machine-generated.

A traveler developed severe sensorimotor neuropathy and skin rash after visiting Goa. Arsenic poisoning was diagnosed via urine tests and treated with chelation therapy, with deliberate poisoning suspected.

Related Experiment Videos

Last Updated: Jun 16, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Area of Science:

  • Toxicology
  • Neurology
  • Dermatology

Background:

  • A 49-year-old man presented with a multi-week history of gastrointestinal distress, weight loss, a desquamating skin rash, and progressive sensorimotor neuropathy.
  • Symptoms developed after a 3-month stay in Goa, India.

Observation:

  • A 49-year-old man presented with vomiting, weight loss, skin rash, and painful sensorimotor neuropathy after 3 months in Goa.
  • Clinical examination revealed mild normocytic anemia and lymphopenia.
  • Nerve conduction studies and sural nerve biopsy confirmed a severe axonal large fiber sensorimotor neuropathy.

Findings:

  • Urine arsenic concentration was significantly elevated at 300 microg/l, confirming arsenic poisoning.
  • Symptoms largely resolved after leaving Goa, except for persistent severe neuropathic symptoms.
  • The patient responded well to chelation therapy.

Implications:

  • This case highlights the importance of considering environmental and toxicological causes, such as arsenic poisoning, in patients with unexplained neurological and dermatological symptoms after international travel.
  • Early diagnosis and intervention, including chelation therapy, are vital for managing arsenic toxicity.
  • Public health awareness regarding arsenic exposure risks in certain travel destinations is warranted.