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Updated: Jun 16, 2026
Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder
Published on: March 4, 2018
A prospective study of SCA3 gait ataxia described through a Markovian method
Suzi Camey1, Laura Bannach Jardim, Christian Kieling
1Department of Statistics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Background:
Studies on the natural history of rare, chronic diseases like spinocerebellar ataxia 3 (SCA3) are hard to be done, since patients enter the study with variable disease durations and are followed up at irregular intervals.
Aims:
Our purpose was to use all the available data to describe the progression of gait ataxia in a long-term cohort of patients with SCA3 through a markovian method.
Materials And Methods:
SCA3 patients were recruited between 1998 and 2005 and were invited to annual neurological follow-ups until 2007. Gait ataxia was described through a mean score graph and a mean trajectory graph.
Results:
We followed up 105 patients; at baseline, the mean age and disease duration were, 40.5 (SD = 12.6) and 7.7 (SD = 5.8) years, respectively. The mean time to reach stages 1, 2, 3 and 4 of gait ataxia were 3, 5.4, 10.8 and 19.4 years of disease duration. The mean score graph was unsmooth, showing several unlikely ups and downs. The mean trajectory graph produced a continuous curve.
Conclusion:
The markovian method described the natural history of gait ataxia without any a posteriori adjustment of data and allowed statistical comparisons between subgroups. This method will be useful in future clinical trials in this and in other chronic degenerative diseases.
