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Hemodiafiltration: clinical evidence and remaining questions
Peter J Blankestijn1, Ingrid Ledebo, Bernard Canaud
1Department of Nephrology, University Medical Center, Utrecht, The Netherlands. P.J.Blankestijn@umcutrecht.nl
Kidney International
|February 5, 2010
Summary
High-flux hemodialysis is common, but hemodiafiltration offers superior solute removal for better patient outcomes. This review examines clinical evidence for hemodiafiltration and identifies knowledge gaps.
Area of Science:
- Nephrology
- Renal Replacement Therapy
Background:
- Two-thirds of global hemodialysis patients use high-flux membranes.
- The presumed benefit is enhanced solute clearance for improved clinical outcomes.
Purpose of the Study:
- To review clinical evidence supporting hemodiafiltration.
- To identify remaining questions regarding hemodiafiltration.
Main Methods:
- Literature review of clinical studies on hemodiafiltration.
- Analysis of existing data on hemodiafiltration efficacy.
Main Results:
- Hemodiafiltration provides superior convective solute removal compared to hemodialysis.
- Despite benefits, hemodiafiltration is underutilized.
Conclusions:
- Hemodiafiltration is a superior modality for convective solute removal.
- Further research is needed to address remaining questions and promote wider adoption.
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