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Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

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Related Experiment Video

Updated: Jun 16, 2026

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation
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Segment-by-segment stabilization for degenerative disc disease: a hybrid technique.

Othmar Schwarzenbach1, Nathalie Rohrbach, Ulrich Berlemann

  • 1Das Rückenzentrum, Bahnhofstrasse 3, 3600, Thun, Switzerland. o.schwarzenbach@dasRueckenzentrum.ch

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
|February 5, 2010
PubMed
Summary

This study shows that combining Dynesys non-fusion implants with posterior lumbar interbody fusion (PLIF) for multisegmental degenerative disc disease (DDD) significantly reduces pain and disability. This segment-by-segment approach is safe and effective for treating multilevel DDD.

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Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
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Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

Area of Science:

  • Spine surgery
  • Orthopedics
  • Neurosurgery

Background:

  • Multisegmental degenerative disc disease (DDD) poses treatment challenges.
  • Surgical options include fusion and non-fusion techniques.
  • Segment-by-segment application of implants offers a novel approach.

Purpose of the Study:

  • To evaluate the clinical and radiological outcomes of a segment-by-segment surgical technique for multilevel DDD.
  • To assess the combined use of Dynesys non-fusion implants and posterior lumbar interbody fusion (PLIF).

Main Methods:

  • A consecutive case series of 31 patients (16 female, 15 male) with a mean age of 53.6 years.
  • Patients underwent segment-by-segment treatment using Dynesys implants (non-fusion) and PLIF (fusion).
  • Clinical outcomes (Oswestry disability index, VAS pain scores) and radiological outcomes (fusion success, system failure) were assessed over a mean follow-up of 39 months.

Main Results:

  • Significant improvements were observed in back pain (7.3 to 3.4), leg pain (6.0 to 2.3), and Oswestry disability index (51.6% to 28.7%).
  • A very low rate of screw loosening (0.45%) was reported.
  • The technique demonstrated high fusion success and no system failures.

Conclusions:

  • Segment-by-segment treatment combining Dynesys non-fusion and PLIF fusion is technically feasible.
  • This combined approach is safe and effective for surgical treatment of multilevel degenerative disc disease.
  • The study supports this hybrid technique for managing complex DDD cases.