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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening

Published on: October 26, 2017

microRNAs and lung cancer: tumors and 22-mers

Liqin Du1, Alexander Pertsemlidis

  • 1Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8807, USA.

Cancer Metastasis Reviews
|February 5, 2010
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cancer. This review explores their role in lung cancer development, progression, and potential as diagnostic and therapeutic tools.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their regulatory roles in disease.
  • Recent research highlights miRNAs' involvement in cancer development and progression.
  • miRNAs are being investigated as potential cancer biomarkers and therapeutic targets.

Purpose of the Study:

  • To review recent advances in understanding miRNAs in tumorigenesis.
  • To focus on miRNA regulation of genes critical to lung cancer.
  • To discuss miRNA's role in malignant transformation, angiogenesis, and metastasis.

Main Methods:

  • Literature review of recent studies on miRNAs and cancer.
  • Analysis of miRNA regulation in lung cancer development.
  • Examination of miRNA dysregulation and its clinical applications.

Main Results:

  • miRNAs play significant roles in regulating genes involved in lung cancer.
  • Dysregulation of miRNA expression is linked to cancer development.
  • miRNAs are implicated in key cancer processes like angiogenesis and metastasis.

Conclusions:

  • miRNAs are crucial regulators in lung cancer pathogenesis.
  • miRNA-based diagnostics and therapeutics show promise for cancer treatment.
  • Further research into miRNA mechanisms can advance cancer care.

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