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Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Related Experiment Video

Updated: Jun 16, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

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Published on: September 15, 2017

Familial hyperaldosteronism I-III.

I Quack1, O Vonend, L C Rump

  • 1Department of Nephrology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|February 5, 2010
PubMed
Summary

Familial hyperaldosteronism, a cause of secondary hypertension, has three types. Identifying affected families allows for targeted treatment, potentially curing or improving the condition.

Area of Science:

  • Endocrinology
  • Genetics
  • Hypertension Research

Background:

  • Primary aldosteronism is the most common cause of secondary hypertension.
  • Three distinct variants of familial hyperaldosteronism are recognized.
  • Heritable forms are characterized by early-onset hypertension and significant target organ damage.

Purpose of the Study:

  • To highlight the importance of identifying familial hyperaldosteronism variants.
  • To emphasize the diagnostic value of detailed family history in uncovering Mendelian inheritance patterns.
  • To underscore the need for accurate differentiation between familial hyperaldosteronism types for effective treatment.

Main Methods:

  • Review of current literature on familial hyperaldosteronism.
  • Analysis of phenotypic variability and genetic underpinnings.

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  • Emphasis on clinical assessment and family history taking.

    • Main Results:

    • Familial hyperaldosteronism type I has an identified genetic defect.
    • Research into the genetic basis of familial hyperaldosteronism types II and III is ongoing.
    • Variable phenotypes can obscure familial inheritance, making thorough family history crucial.

    Conclusions:

    • Identifying affected families with familial hyperaldosteronism is highly beneficial, enabling potential cures or specific treatments.
    • Early detection through family screening can allow for preemptive treatment of relatives.
    • Precise differentiation among the three subtypes is essential to guide appropriate medical or surgical interventions and avoid unnecessary therapies.