Related Experiment Video
Updated: Jun 16, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
Signal transduction pathways that function in both development and innate immunity
Frederick A Partridge1, Maria J Gravato-Nobre, Jonathan Hodgkin
1Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Abstract:
C. elegans is developing in importance as a model for innate immunity. Several signaling pathways are known to be required for immune responses to a diverse range of pathogens, including the insulin signaling, p38 MAP kinase and transforming growth factor-beta pathways. These pathways also have roles during development, which can complicate the analysis of their functions in immunity. Recent studies have suggested that immunity in C. elegans is integrated across the organism by both paracrine and neuronal communication, showing the complexity of the immune system in this organism.
More Related Videos
Related Concept Videos
Signal Transduction: Overview
Typically, signal transduction involves three...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
Amplifying Signals via Second Messengers
Intracellular Signaling Cascades
Intracellular Signaling Cascades

