Related Experiment Video
Updated: Jun 16, 2026
04:49
Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
Published on: February 11, 2022
Inflammatory abdominal aortic aneurysm (IAAA)
Guido Bajardi1, Felice Pecoraro, Domenico Mirabella
1Cattedra di Chirurgia Vascolare, Università degli Studi di Palermo, Italy. guidobajardi@libero.it
Annali Italiani Di Chirurgia
|February 6, 2010
Summary
Inflammatory abdominal aortic aneurysm (IAAA) requires preventive treatment similar to non-inflammatory abdominal aortic aneurysm (AAA) due to comparable rupture rates. Open repair is a viable surgical option for IAAA.
Area of Science:
- Vascular Surgery
- Abdominal Aortic Aneurysm Research
- Inflammatory Conditions
Background:
- Inflammatory abdominal aortic aneurysm (IAAA) is a distinct subtype of abdominal aortic aneurysm (AAA).
- Understanding the specific characteristics and treatment outcomes of IAAA is crucial for effective patient management.
Purpose of the Study:
- To present the surgical experience and outcomes of treating eight cases of inflammatory abdominal aortic aneurysm (IAAA).
- To evaluate diagnostic methods and surgical approaches for IAAA.
Main Methods:
- Retrospective review of 8 IAAA cases treated between 1999 and 2008.
- Preoperative diagnosis utilized ultrasound (US), computed tomography (CT), and intravenous urography (IVU).
- All patients underwent open surgical repair via midline incision and transperitoneal access.
Main Results:
- No 30-day mortality was observed in the treated cohort.
- One patient experienced pancreatitis, managed conservatively.
- All patients received 60-day corticosteroid therapy post-surgery.
Conclusions:
- IAAA shares similar rupture risks with AAA, necessitating comparable preventive treatment strategies.
- Open surgical repair is a suitable approach for IAAA, with treatment criteria mirroring those for AAA.
- Further research is needed on endovascular aneurysm repair (EVAR) for IAAA, particularly regarding biopsy acquisition and retroperitoneal fibrosis regression.
Related Concept Videos
01:26Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
01:30Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
01:15Aortic Regurgitation I: Introduction
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
01:19Appendicitis
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...