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Related Concept Videos

Cellular Adaptation III: Hyperplasia01:26

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Hyperglycemia01:29

Hyperglycemia

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Related Experiment Video

Updated: Jun 16, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

[Gingival hyperplasia].

Christiane De Rop1, Gesine Picksak, Dirk O Stichtenoth

  • 1Institut für Klinische Pharmakologie der Medizinische Hochschule Hannover, Hannover.

Medizinische Monatsschrift Fur Pharmazeuten
|February 6, 2010
PubMed
Summary
This summary is machine-generated.

Gingival hyperplasia, a side effect of medications like phenytoin, calcium channel blockers, and cyclosporine, can be managed by altering drug regimens or maintaining rigorous oral hygiene. This condition is reversible upon discontinuation or modification of the causative therapy.

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Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

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Last Updated: Jun 16, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

Area of Science:

  • Oral Medicine
  • Pharmacology
  • Pathology

Context:

  • Gingival hyperplasia is a known adverse drug reaction.
  • Certain medications including phenytoin, calcium antagonists, and cyclosporine are commonly implicated.
  • Hormonal therapies and oral contraceptives may also rarely contribute.

Purpose:

  • To review the causes and management of drug-induced gingival hyperplasia.
  • To highlight the importance of differential diagnosis, including paraneoplastic syndromes.
  • To emphasize reversible treatment strategies.

Summary:

  • Drug-induced gingival hyperplasia is a common side effect of specific medications.
  • Discontinuation or modification of the offending drug therapy is the primary treatment.
  • In cases where medication change is not feasible, meticulous oral hygiene and professional prophylaxis are crucial for management.

Impact:

  • Provides clinicians with essential information for diagnosing and managing gingival hyperplasia.
  • Underscores the significance of medication review in patients presenting with gingival overgrowth.
  • Highlights the reversibility of the condition and the critical role of patient compliance with oral care.