Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates
07:19

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates

Published on: March 7, 2014

Interaction of parylene C with biological objects.

Marta Kamińska1, Wiesława Okrój, Witold Szymański

  • 1Institute of Materials Science and Engineering and the Centre of Excellence NANODIAM, Technical University of Łódź, Poland.

Acta of Bioengineering and Biomechanics
|February 6, 2010
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The influence of platelets and platelet-derived extracellular vesicles on the injury of cardiomyocytes under static hypoxia/reoxygenation conditions.

Scientific reports·2026
Same author

Immunomodulatory endothelial cells contribute to T cell recruitment and activation via antigen presentation on MHC II.

Cardiovascular research·2026
Same author

A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence.

Cell communication and signaling : CCS·2026
Same author

Corrigendum to "Metabolic plasticity and optimal redox homeostasis are essential for efficient metastatic colonization" [Mol Metab 109 (2026) 102382/42155637].

Molecular metabolism·2026
Same author

Tribological Behavior of Silver-Doped Diamond-like Carbon Coatings in Air and Simulated Biological Environments.

Materials (Basel, Switzerland)·2026
Same author

Reply to Li and Ni "Positive Airway Pressure Therapy for Cognitive Enhancement in Parkinson's Disease: From Statistical Signals to Clinical Practice".

Sleep·2026

Parylene C shows potential for biomedical applications, with varied effects on platelet adhesion based on surface texture. Protein adsorption is high, influencing bacterial colonization and endothelial cell responses.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cell Biology

Background:

  • Parylene C is a polymer used in various applications, including potential biomedical uses.
  • Understanding its interaction with biological components is crucial for evaluating its safety and efficacy.

Purpose of the Study:

  • To investigate the interactions of parylene C with blood plasma proteins, platelets, endothelial cells, and bacterial biofilm.
  • To assess the suitability of parylene C for biomedical applications based on these interactions.

Main Methods:

  • Coating medical steel substrates with parylene C.
  • Assessing platelet adhesion on polished and machined surfaces.
  • Evaluating plasma protein adsorption.
  • Analyzing bacterial colonization (E. coli biofilm).

More Related Videos

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

Surface Passivation for Single-molecule Protein Studies
10:35

Surface Passivation for Single-molecule Protein Studies

Published on: April 24, 2014

Related Experiment Videos

Last Updated: Jun 16, 2026

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates
07:19

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates

Published on: March 7, 2014

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

Surface Passivation for Single-molecule Protein Studies
10:35

Surface Passivation for Single-molecule Protein Studies

Published on: April 24, 2014

  • Investigating endothelial cell proliferation and gene expression.

    • Main Results:

    • Parylene C coating reduced platelet adhesion on polished steel but increased it on machined steel, highlighting substrate topography influence.
    • Effective adsorption of plasma proteins onto the parylene C surface was observed.
    • High susceptibility of parylene C to bacterial colonization was noted.
    • Reduced endothelial cell proliferation and altered gene expression were observed.

    Conclusions:

    • Parylene C exhibits complex interactions with biological systems, necessitating careful consideration for specific biomedical uses.
    • Surface texture significantly impacts parylene C's interaction with platelets.
    • Protein adsorption mediates cell interactions and contributes to bacterial adhesion.
    • Further analysis of endothelial cell responses is required for vascular applications.