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Related Concept Videos

Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
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In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
Silica particles offer advantages such as rigidity,...

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Extraction of Plant-based Capsules for Microencapsulation Applications
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Published on: November 9, 2016

Another paradigm in solvent extraction-based microencapsulation technologies.

Hye-Yeum Im1, Jayoung Kim, Hongkee Sah

  • 1College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-gu, Seoul 120-750, Republic of Korea.

Biomacromolecules
|February 6, 2010
PubMed
Summary
This summary is machine-generated.

A novel base-driven reaction enables efficient microencapsulation of progesterone using poly-D,L-lactide-co-glycolide microspheres. This technique avoids quenching liquids and preserves drug and polymer integrity, offering a promising alternative for drug delivery systems.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Drug Delivery

Background:

  • Polymeric microspheres are crucial for controlled drug release.
  • Traditional microencapsulation methods often involve harsh chemicals or multiple steps.
  • Developing efficient and mild techniques for microsphere preparation is essential.

Purpose of the Study:

  • To develop a novel microencapsulation technique using a base-driven reaction.
  • To prepare progesterone-loaded poly-D,L-lactide-co-glycolide (PLGA) microspheres.
  • To investigate the efficiency and characteristics of the base-driven microencapsulation process.

Main Methods:

  • Utilized a base-driven reaction with nonhalogenated ester solvents (ethyl acetate, ethyl formate) for PLGA microsphere preparation.
  • Formed an oil-in-water emulsion, followed by addition of sodium hydroxide to initiate solvent hydrolysis.
  • Monitored microsphere solidification, encapsulation efficiency, and residual solvent content.

Main Results:

  • Achieved microsphere solidification within 15-30 minutes without quenching liquid.
  • Ethyl formate demonstrated a 2.3 times faster reaction rate compared to ethyl acetate.
  • High drug encapsulation efficiency (>93.2%) and low residual solvent content (1.87-2.69%) were obtained.
  • Gel Permeation Chromatography (GPC) and Fourier-Transform Infrared Spectroscopy (FTIR) confirmed polymer and drug structural integrity.

Conclusions:

  • The base-driven reaction is an effective method for progesterone-loaded PLGA microsphere preparation.
  • This technique offers a rapid, efficient, and mild alternative to conventional microencapsulation.
  • The method shows potential for the scalable production of nanoparticles and microspheres for pharmaceutical applications.