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Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
Intracellular delivery of a membrane-impermeable enzyme in active form using functionalized gold nanoparticles
Partha Ghosh1, Xiaochao Yang, Rochelle Arvizo
1Department of Chemistry, University of Massachusetts at Amherst, Amherst, Massachusetts 01003, USA.
Journal of the American Chemical Society
|February 6, 2010
Abstract:
Gold nanoparticles were coated with a short peptide to promote intracellular delivery of membrane-impermeable proteins. Through microscopy and enzyme assays, we demonstrated the particles were able to transport functional enzymes into a variety of cell lines. Significantly, the transported proteins were able to escape from endosomes. Moreover, these particles showed no apparent cytotoxicity.

