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Updated: Jun 16, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

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Published on: May 6, 2014

Proinflammatory status, genetics and atherosclerosis.

R Poledne1, A Lorenzová, P Stávek

  • 1Center for Cardiovascular Research, Prague, Czech Republic. rudolf.poledne@ikem.cz

Physiological Research
|February 6, 2010
PubMed
Summary
This summary is machine-generated.

High-sensitivity C-reactive protein (hsCRP) indicates cardiovascular risk, correlating with obesity and triglycerides. Factors like sex, age, and genetics influence hsCRP levels, impacting atherosclerosis development.

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12:43

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Last Updated: Jun 16, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

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Published on: May 6, 2014

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Public Health

Background:

  • High-sensitivity C-reactive protein (hsCRP) is a recognized marker for premature atherosclerosis.
  • Elevated hsCRP (>2 mg/l) signifies increased risk for myocardial infarction and stroke, though its clinical application is complex.
  • hsCRP levels are influenced by various cardiovascular risk factors.

Purpose of the Study:

  • To investigate the relationship between hsCRP and cardiovascular risk factors in a large population sample.
  • To explore sex-specific differences in hsCRP concentration concerning age.
  • To examine the impact of physical activity on hsCRP in obese women and its relation to interleukin-6.
  • To assess the genetic influence on hsCRP levels, particularly concerning coronary atherosclerosis and lipoprotein metabolism genes.

Main Methods:

  • Analysis of hsCRP concentrations in a 1% representative sample of the Czech population.
  • Correlation analysis of hsCRP with Body Mass Index (BMI), waist circumference, and triglyceride levels.
  • Investigation of sex and age-related differences in hsCRP.
  • Assessment of hsCRP changes following physical activity interventions in obese women.
  • Evaluation of genetic factors, including apolipoprotein CI and E genes, influencing hsCRP.

Main Results:

  • A positive correlation was found between hsCRP, BMI, waist circumference, and triglyceride levels.
  • Significant sex differences in hsCRP were observed concerning age: continuous increase in men, post-menopausal increase in women.
  • Physical activity led to decreased hsCRP in young obese women, independent of interleukin-6 levels.
  • Genetic factors, specifically genes for apolipoprotein CI and E, were found to influence hsCRP concentrations.
  • Higher hsCRP was documented in young siblings of individuals with coronary atherosclerosis.

Conclusions:

  • hsCRP is a valuable marker for premature atherosclerosis, linked to central obesity and triglyceride metabolism.
  • Sex and age significantly modulate hsCRP levels, with distinct patterns in men and women.
  • Lifestyle interventions like physical activity can reduce hsCRP in specific populations.
  • Genetic predisposition plays a role in determining hsCRP levels, highlighting its complex etiology.
  • Further research is warranted to explore the role of monocyte properties in hsCRP-related atherogenesis.