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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 16, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Prognostic markers in osteosarcoma.

Sameer Bakhshi¹, Venkatraman Radhakrishnan

¹Department of Medical Oncology, Dr B R A Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029, India. sambakh@hotmail.com

Expert Review of Anticancer Therapy

|February 6, 2010

Summary

This summary is machine-generated.

New molecular markers and advanced imaging show promise for improving osteosarcoma survival. These tools may help predict patient outcomes and guide targeted therapies for this common pediatric bone cancer.

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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

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Last Updated: Jun 16, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Area of Science:

Oncology
Molecular Biology
Medical Imaging

Background:

Osteosarcoma is the most prevalent bone tumor in pediatric and adolescent populations.
While multiagent chemotherapy has improved survival rates from 20% to 65% since the 1980s, further significant improvements are limited.
Lack of validated prognostic markers and novel therapeutic agents hinders progress in osteosarcoma treatment.

Purpose of the Study:

To explore the potential of novel molecular markers in osteosarcoma.
To investigate the role of angiogenesis, cell adhesion, apoptosis, and cell cycle markers.
To assess the utility of noninvasive imaging techniques for prognostication and treatment response evaluation.

Main Methods:

Review of recent findings on molecular markers in osteosarcoma.
Analysis of the role of specific cellular pathways (angiogenesis, apoptosis, etc.).
Evaluation of advanced noninvasive imaging modalities like PET-CT and MRI.

Main Results:

Molecular markers associated with angiogenesis, cell adhesion, apoptosis, and cell cycle are implicated in osteosarcoma progression and metastasis.
Emerging molecular markers offer potential for baseline prognostication.
Noninvasive imaging methods (PET-CT, MRI) show promise for prognostication and response assessment.

Conclusions:

New molecular markers could serve as prognostic tools and therapeutic targets for osteosarcoma.
Advanced imaging techniques hold potential as surrogate markers for predicting patient outcomes.
Further research into these areas may lead to improved survival rates for osteosarcoma patients.