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Comet Assay as an Indirect Measure of Systemic Oxidative Stress
Published on: May 22, 2015
Exercise in systemic sclerosis intensifies systemic inflammation and oxidative stress.
H Hargardóttir1, H A C van Helvoort, M C Vonk
1Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, The Netherlands.
Scandinavian Journal of Rheumatology
|February 6, 2010
Summary
Systemic sclerosis (SSc) patients show impaired exercise capacity and heightened inflammation. Physical activity worsens systemic inflammation and oxidative stress, suggesting their role in SSc progression.
Area of Science:
- Cardiopulmonary exercise testing
- Systemic sclerosis research
- Inflammation and oxidative stress markers
Background:
- Systemic sclerosis (SSc) is a connective tissue disease characterized by inflammation and fibrosis.
- Exercise testing can reveal functional limitations in SSc patients.
- The impact of physical activity on inflammatory and oxidative pathways in SSc is not fully understood.
Purpose of the Study:
- To evaluate exercise-induced inflammatory and oxidative responses in SSc patients.
- To compare these responses with those of healthy individuals.
- To correlate exercise responses with disease severity in SSc.
Main Methods:
- Maximal cardiopulmonary exercise testing (CPET) was performed on 11 SSc patients and 10 healthy controls.
- Continuous monitoring of physiological responses during cycling.
- Blood samples were analyzed for inflammatory and oxidative markers at rest, during, and after exercise.
Main Results:
- SSc patients exhibited limited exercise capacity due to cardiocirculatory and gas exchange impairments.
- Elevated basal levels of inflammatory cells, IL-6, and oxidative stress were observed in SSc patients.
- Exercise intensified inflammation and oxidative stress in SSc patients, correlating with the modified Rodnan skin score.
Conclusions:
- Exercise capacity is reduced in SSc patients.
- Physical activity exacerbates pre-existing systemic inflammation and oxidative stress in SSc.
- These findings support the involvement of inflammation and oxidative stress in the systemic manifestations of SSc.
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