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Updated: Jun 16, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Effect of cocaine use on buprenorphine pharmacokinetics in humans
Elinore F McCance-Katz1, Petrie M Rainey, David E Moody
1Department of Psychiatry, University of California San Francisco, San Francisco, California, USA. elinore.mccance-katz@ucsf.edu
Abstract:
The effect of chronic cocaine use on buprenorphine pharmacokinetics was investigated to identify drug interactions and potential toxicities. In a retrospective analysis, pharmacokinetics were compared for 16 studies completed on subjects who were regular cocaine users and 74 studies on subjects who used cocaine only occasionally or not at all. All participants were stably maintained on buprenorphine/naloxone 16/4 mg daily. Participants who used cocaine regularly had lower buprenorphine exposure (AUC 34% lower; C(max) 27% lower and C(24) 37% lower; p
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