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Related Concept Videos

Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
GPCR Desensitization01:12

GPCR Desensitization

G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
Deindividuation00:57

Deindividuation

Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
Sensation01:21

Sensation

Sensory receptors are specialized neurons that respond to specific types of external stimuli, initiating the process known as sensation. This occurs when sensory input, such as light entering the eye, is detected by these receptors, causing chemical changes in the cells of the retina. These cells then convert the sensory stimulus into action potentials that are transmitted to the central nervous system, a process termed transduction.
Absolute thresholds can quantify the sensitivity of sensory...
Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...

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Articles linked to this work by shared authors, journal, and citation graph.

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Posttransplant reduction in preexisting donor-specific antibody levels after belatacept- versus cyclosporine-based immunosuppression: Post hoc analyses of BENEFIT and BENEFIT-EXT.

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Related Experiment Video

Updated: Jun 16, 2026

Desensitization and Recovery of Crayfish Photoreceptors Upon Delivery of a Light Stimulus
06:43

Desensitization and Recovery of Crayfish Photoreceptors Upon Delivery of a Light Stimulus

Published on: November 9, 2019

Making sense of desensitization.

H M Gebel, P F Halloran

    American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
    |February 6, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Desensitization plus paired exchange may be a viable strategy for renal transplantation. Further research is needed to confirm its effectiveness and safety in kidney transplant recipients.

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    Published on: May 9, 2019

    Area of Science:

    • Nephrology
    • Immunology
    • Transplantation Science

    Background:

    • Renal transplantation is a critical treatment for end-stage renal disease.
    • Desensitization protocols aim to reduce antibody-mediated rejection.
    • Paired exchange programs increase the donor pool for incompatible recipients.

    Discussion:

    • Evaluating the efficacy of combined desensitization and paired exchange is crucial.
    • Assessing the long-term outcomes and patient survival rates is necessary.
    • Addressing potential risks and complications associated with this combined approach is important.

    Key Insights:

    • The combination of desensitization and paired exchange offers a potential solution for highly sensitized patients.
    • Careful patient selection and management are vital for successful outcomes.
    • This strategy may expand the eligibility criteria for kidney transplantation.

    Outlook:

    • Further clinical trials are required to validate this approach.
    • Long-term monitoring of graft function and patient health is essential.
    • This strategy could significantly improve access to kidney transplants for many patients.