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Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Inflammation

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Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: Jun 16, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Epigenetics in atherosclerosis and inflammation.

Rutger J Wierda¹, Sacha B Geutskens, J Wouter Jukema

¹Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

Journal of Cellular and Molecular Medicine

|February 6, 2010

Summary

This summary is machine-generated.

Epigenetic mechanisms, like DNA methylation and histone modifications, are crucial in atherosclerosis development. Targeting these reversible processes offers promising therapeutic strategies for this inflammatory vascular disease.

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Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

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Last Updated: Jun 16, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Area of Science:

Cardiovascular Biology
Immunology
Epigenetics

Background:

Atherosclerosis is a major health issue driven by chronic inflammation.
Vascular wall cells express immunoregulatory molecules in atherosclerotic lesions.
Epigenetic mechanisms, including DNA methylation and histone modifications, control gene expression.

Purpose of the Study:

To review the role of epigenetic regulation in inflammation and atherosclerosis.
To highlight potential therapeutic interventions targeting epigenetic mechanisms.

Main Methods:

Literature review focusing on epigenetic mechanisms in atherosclerosis.
Discussion of the link between inflammation and epigenome reprogramming.

Main Results:

Epigenetic modulators are critical for gene expression in atherosclerotic lesions.
Epigenetic processes are reversible and represent potential therapeutic targets.
Recent research links inflammation to epigenome reprogramming in atherosclerosis.

Conclusions:

Epigenetic regulation is increasingly recognized as a key factor in atherosclerosis pathogenesis.
Targeting epigenetic mechanisms offers a promising avenue for treating atherosclerosis.