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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
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An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
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Related Experiment Video

Updated: Jun 16, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

[Circadian rhythms and systems biology].

Albert Goldbeter1, Claude Gérard, Jean-Christophe Leloup

  • 1Unité de chronobiologie théorique, Université Libre de Bruxelles, Campus Plaine, CP 231, B-1050 Bruxelles, Belgique. agoldbet@ulb.ac.be

Medecine Sciences : M/S
|February 6, 2010
PubMed
Summary

Cellular rhythms, like circadian rhythms and the cell cycle, emerge from complex regulatory networks. Mathematical models help understand these biological oscillations and related disorders.

Area of Science:

  • Systems biology
  • Cellular dynamics
  • Biophysical modeling

Context:

  • Cellular rhythms, including circadian rhythms and the cell cycle, are fundamental biological processes.
  • Understanding the conditions for spontaneous periodic behavior in cellular regulatory networks is crucial.
  • Experimental and modeling approaches are key to studying these phenomena.

Purpose:

  • To explore how regulatory network structures lead to emergent periodic behavior in cells.
  • To investigate the dynamical underpinnings of circadian rhythms and the cell cycle.
  • To model the impact of dysfunctions in these cellular rhythms, such as in mammalian circadian clock disorders.

Summary:

  • Cellular rhythms arise from complex regulatory networks, exemplified by circadian rhythms (clock gene feedback loops) and the cell cycle (cyclin-dependent kinase networks).

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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Related Experiment Videos

Last Updated: Jun 16, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

  • Mathematical modeling clarifies how these networks generate oscillations, an emergent property dependent on system structure.
  • These models aid in understanding physiological disorders linked to disruptions in cellular rhythms.

    • Impact:

    • Provides insights into the fundamental principles of biological oscillations.
    • Facilitates the study of diseases associated with circadian rhythm and cell cycle dysregulation.
    • Highlights the power of systems biology and modeling in understanding complex cellular functions.