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Radioactive Decay and Radiometric Dating02:48

Radioactive Decay and Radiometric Dating

Radioactivity is a spontaneous disintegration of an unstable nuclide and is a random process, as all the nuclei in the sample do not decay simultaneously. The number of disintegrations per unit time is called the activity (A), which is directly proportional to the number of nuclei in the sample. The decay constant (λ) is an average probability of decay per nucleus in unit time.
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Related Experiment Video

Updated: Jun 16, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

Activity standardization and decay data of 64Cu.

Carsten Wanke1, Karsten Kossert, Ole J Nähle

  • 1Physikalisch-Technische Bundesanstalt, Braunschweig, Germany. carsten.wanke@ptb.de

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|February 6, 2010
PubMed
Summary

Accurate measurement of Copper-64 activity was achieved using advanced counting techniques. This study determined its half-life and photon emission probabilities, crucial for nuclear medicine applications.

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Automated 90Sr Separation and Preconcentration in a Lab-on-Valve System at Ppq Level

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Area of Science:

  • Nuclear Physics
  • Radiochemistry
  • Metrology

Background:

  • Accurate quantification of radionuclides is essential for applications in nuclear medicine, research, and industry.
  • Copper-64 (64Cu) is a positron-emitting isotope with significant potential in diagnostic imaging and targeted radiotherapy.
  • Standardization of 64Cu activity is critical for ensuring consistency and comparability of measurements worldwide.

Purpose of the Study:

  • To accurately determine the activity of a 64Cu solution using multiple high-precision counting methods.
  • To measure the half-life and photon emission probabilities of 64Cu.
  • To contribute to the international standardization of 64Cu through submission to the International Reference System (SIR).

Main Methods:

  • 4πβ(PC)γ coincidence counting and liquid scintillation counting (CIEMAT/NIST method) for activity determination.
  • 4π ionization chambers for calibration factor establishment and half-life measurement.
  • Gamma-ray spectrometry for determining photon emission probabilities.

Main Results:

  • A precise half-life of 12.704(5) hours was measured for 64Cu.
  • Photon emission probabilities were determined: p(511 keV)=0.3512(22) and p(1346 keV)=0.00474(5).
  • The first entry for 64Cu in the BIPM's International Reference System (SIR) database was established, validating the activity measurement.

Conclusions:

  • The study provides reliable metrological data for 64Cu, including its activity, half-life, and photon emission probabilities.
  • These findings enhance the accuracy of 64Cu-based measurements, supporting its use in nuclear medicine and research.
  • The successful entry into the SIR database signifies international recognition of the measurement's quality and traceability.