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Related Experiment Video

Updated: Jun 16, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Physical activity and albuminuria.

Emily S Robinson¹, Naomi D Fisher, John P Forman

¹Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women'sHospital, and Harvard Medical School, Boston, Massachusetts 02115, USA. erobinson11@partners.org

American Journal of Epidemiology

|February 6, 2010

Summary

This summary is machine-generated.

Regular physical activity is linked to lower albuminuria in nondiabetic women. Higher activity levels, including strenuous exercise and walking, were associated with reduced albumin/creatinine ratio (ACR), a marker for kidney disease risk.

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Area of Science:

Nephrology
Cardiovascular Health
Exercise Physiology

Background:

Elevated urinary albumin excretion (albuminuria) is a predictor of cardiovascular disease, hypertension, and chronic kidney disease.
Physical activity is known to improve endothelial function and has been shown to decrease albuminuria in diabetic individuals.
Previous studies found no association between physical activity and albuminuria in non-diabetic populations.

Purpose of the Study:

To investigate the cross-sectional association between physical activity and albuminuria in a large cohort of nondiabetic women.
To determine if different types of physical activity, such as strenuous exercise and walking, are associated with albuminuria levels.

Main Methods:

The study analyzed data from 3,587 nondiabetic women from the Nurses' Health Study I and II.
Physical activity was quantified using metabolic equivalents per week.
Albuminuria was assessed by the albumin/creatinine ratio (ACR), with the top decile as the outcome, analyzed using multivariate logistic regression.

Main Results:

Women in the highest physical activity quintile had a significantly lower odds of being in the top ACR decile (OR: 0.65, 95% CI: 0.46, 0.93) compared to those in the lowest quintile.
Greater than 210 minutes per week of strenuous activity was associated with reduced odds of the top ACR decile (OR: 0.61, 95% CI: 0.37, 0.99).
Higher levels of walking were also associated with lower odds of the top ACR decile (OR: 0.69, 95% CI: 0.47, 1.02).

Conclusions:

Increased physical activity is associated with a lower albumin/creatinine ratio in nondiabetic women.
These findings suggest that physical activity may play a protective role against kidney damage in nondiabetic women.
Promoting physical activity could be a strategy to reduce the risk of kidney disease in this population.