Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resective temporal lobe surgery in refractory temporal lobe epilepsy: prognostic factors of postoperative seizure outcome.

Journal of neurosurgery·2026
Same author

T1w/T2w Ratio Identifies the Basolateral Amygdala as a Preferential Target in Autoimmune Limbic Encephalitis.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2026
Same author

Distinct neuronal populations in the human brain combine content and context.

Nature·2026
Same author

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks.

Nature neuroscience·2025
Same author

Concept and location neurons in the human brain provide the 'what' and 'where' in memory formation.

Nature communications·2024
Same author

Long-term seizure outcome after epilepsy surgery of neuroglial tumors.

Frontiers in neurology·2024

Related Experiment Video

Updated: Jun 16, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
07:25

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Cross-frequency coupling supports multi-item working memory in the human hippocampus.

Nikolai Axmacher1, Melanie M Henseler, Ole Jensen

  • 1Department of Epileptology, University of Bonn, Bonn 53105, Germany. nikolai.axmacher@ukb.uni-bonn.de

Proceedings of the National Academy of Sciences of the United States of America
|February 6, 2010
PubMed
Summary

The human hippocampus maintains multiple items in working memory (WM) using synchronized neural activity. This study links cross-frequency coupling in the hippocampus to WM performance, revealing a neural code based on oscillatory phase information.

More Related Videos

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
04:44

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Published on: February 16, 2024

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Related Experiment Videos

Last Updated: Jun 16, 2026

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
07:25

Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

Published on: August 20, 2020

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
04:44

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex

Published on: February 16, 2024

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Human Electrophysiology

Background:

  • The hippocampus is crucial for memory, but its role in working memory (WM) for multiple items is not fully understood.
  • Theoretical models propose synchronized neural assemblies and cross-frequency coupling for multi-item WM maintenance.

Purpose of the Study:

  • To investigate the neural mechanisms of multi-item working memory maintenance in the human hippocampus.
  • To test predictions from theoretical models linking neural oscillations to working memory capacity.

Main Methods:

  • Intracranial electroencephalography (EEG) recordings in human epilepsy patients.
  • Analysis of hippocampal oscillatory activity and cross-frequency coupling during working memory tasks.

Main Results:

  • Simultaneous maintenance of multiple items in WM correlated with hippocampal cross-frequency coupling.
  • Increased item load modulated beta/gamma amplitude by theta phase, supporting theoretical predictions.
  • The precision of cross-frequency coupling predicted individual working memory performance.

Conclusions:

  • Human working memory relies on a neural code utilizing phase information within hippocampal oscillations.
  • Cross-frequency coupling in the hippocampus is a key mechanism for maintaining multiple items in working memory.